Collagen, skin, hair and gene data
The papers differ in more than their outcomes. These are the differences I would take into the next conversation about copper peptides.
Skin and delivery
Start with the collagen-synthesis experiment in human fibroblast cultures for a definite cellular result. The skin-regeneration review gathers clinical and cell findings; the anti-wrinkle review puts skin permeability beside the cosmetic argument. I regard the human-skin penetration experiment as a particularly useful companion to both.
Hair and compound identity
The human hair-count trial tested a complex of GHK and 5-aminolevulinic acid. The isolated-follicle and cell study tested the related compound AHK-Cu. Their results have different owners in a very literal sense: different preparations, studied in different settings.
Broader biological arguments
The gene-data review is where the large expression figures and repair-related gene sets enter the discussion. The tissue-remodeling review gathers a broad range of human and animal work. I appreciate their scope most when it sharpens my question about a particular outcome.
- Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ ↗
- GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration ↗
- Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective ↗
- Human skin penetration of a copper tripeptide in vitro as a function of skin layer ↗
- Efficacy of a Complex of 5-Aminolevulinic Acid and Glycyl-Histidyl-Lysine Peptide on Hair Growth ↗
- The effect of tripeptide-copper complex on human hair growth in vitro ↗
- Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data ↗
- The human tri-peptide GHK and tissue remodeling ↗